“Especially after age 60, men die faster than women. They appear to biologically age more rapidly “the author of the new study explains.
Scientists have discovered new evidence that may explain why males often live shorter lives than women.
This is connected to the loss of the Y chromosome, which can damage the heart muscle and lead to fatal heart failure, according to research.
Approximately forty percent of 70-year-olds are affected by the loss of this male chromosome, but they could benefit from a treatment that targets hazardous tissue scarring.
Each cell’s chromosomes are DNA bundles that come in pairs. Men have one X and one Y chromosome, while women have two X chromosomes.
The University of Virginia’s Professor Kenneth Walsh stated: “Especially around age 60, men die faster than women. They appear to biologically age more rapidly.”
He added, “This new study sheds light on why men live shorter lives than women.”
Kenneth Walsh, a researcher at the University of Virginia (UVA), stated that pirfenidone may mitigate the negative impacts of chromosomal loss.
As men age, they begin to lose Y chromosomes in a fraction of their cells, which appears to be especially true for smokers.
Scientists have previously determined that men with Y chromosome deficiency are more likely to die at a younger age and to develop age-related diseases such as Alzheimer’s.
The new research is believed to be the first definitive proof that chromosomal deletion directly causes negative health impacts in men.
Using gene-editing technology, researchers created a unique mouse model to better comprehend the impact of Y chromosome deletion in the blood.
The loss increased age-related disorders, rendered the mice more susceptible to heart scarring, and hastened their demise.
In addition to examining the impact of Y chromosome deletion in human males, the researchers conducted three analyses using UK Biobank data. They discovered a correlation between Y chromosome deletion and cardiovascular disease and heart failure.
Researchers discovered that as chromosomal loss increased, so did the probability of mortality.
Targeting the impacts of Y chromosome loss could help men live longer, healthier lives, according to their results.
