The awards are widely regarded as predictors of the Academy Awards, which will be conducted next month.
Everything Everywhere All At Once has won the Screen Actors Guild award for outstanding film cast.
The sci-fi adventure film follows a middle-aged Chinese-American immigrant and her husband as they scramble to complete their taxes while the Internal Revenue Service audits their laundromat.
Michelle Yeoh won the award for the best female main actor, while Ke Huy Quan won best male supporting actor and Jamie Lee Curtis won best female supporting actor.
Yeoh, upon receiving her trophy at the ceremony in Los Angeles, stated: “This is not just for me”.
This is for every young lady who resembles me.
“I appreciate you offering me a seat at the table.”
Quan, a Vietnamese-American actor who was a child star before taking a lengthy hiatus from acting, stated that he was the first Asian to win in his category.
He added: “When I quit acting, it was because there were so few opportunities.
“The landscape has changed drastically since before.
“Thank you to everyone in this room who contributed to these reforms.”
“I’m 64 years old and this is just incredible,” said Curtis, who portrayed the tax agent in the film.
Other victors included Brendan Fraser for best male film actor in The Whale, Abbott Elementary for best TV comedy ensemble, and The White Lotus for best drama series.
For her role as country singer Tammy Wynette in George & Tammy. Jessica Chastain was named best female actor in a limited series.
Sam Elliott earned the award for best male actor in a limited series for his role as a cowboy in the Yellowstone spinoff 1883.
Jean Smart won the award for best female actor in a comedy, but her co-star Christopher McDonald accepted it on her behalf as she is recuperating from a heart procedure.
Jeremy Allen White, who plays The Bear, won the award for the best comic actor.
The Screen Actors Guild Awards are widely regarded as a precursor to the Academy Awards next month.