Scottish university researchers determined that the mutated genes likely originated at least 250 years ago from a foundational Orkney islander.
A gene mutation that increases the risk of breast and ovarian cancer has been associated with individuals of Orkney descent.
Scientists from the universities of Aberdeen and Edinburgh have discovered that one in 100 individuals with ancestors from the islands off the northeastern coast of Scotland carry a mutation in the BRCA1 gene.
According to the research, it is probable that the gene variant originated from one of the founding members of Westray, an Orkney island with fewer than 600 inhabitants, at least 250 years ago.
The gene mutation was repeatedly identified in cancer-stricken women from Orkney. The majority of whom could also trace their ancestry to the small island of Westray.
As a consequence of these findings, it is planned to offer free testing for the gene variant to anyone living on the Scottish islands who has a grandparent born in Westray, regardless of their family history with the disease.
Professor Zosia Miedzybrodzka, director of the NHS North of Scotland Genetic Service, clarified that harboring the BRCA1 variant is not the sole cause of cancer.
Everyone carries the BRCA genes, but not everyone carries mutations.
Prof. Miedzybrodzka stated, “There are numerous complex factors, and some individuals with gene mutations will not develop cancer.” We do know, however, that diagnostics and appropriate follow-up can save lives.
She advised risk-reduction surgery, breast MRI scanning at 30, and lifestyle changes for women with the gene mutation.
Angelina Jolie’s double mastectomy a decade ago, following the loss of her mother to ovarian cancer. And the subsequent discovery that she possessed a BRCA1 variant, increased public awareness of the defective gene.
The NHS recommends consulting your health care physician if you or a family member has cancer. They may recommend a genetic test to discover if you have a cancer-risk gene.
